4- (substituted cycloalkylmethyl) imidazol-2-thione, 4- (substituted cycloalkenylmethyl) imidazole-2-thione, 4- (substituted cycloalkylmethyl) imidazole-2-ones and 4- (substituted cycloalkenylmethyl) imidazole-2-ones ) and related compounds

摘要

"4- (4-Cycloalkylmethyl) Imidazole-2-Tones, 4- (4-Cycloalkylmethyl-Imidazole), 4- (4-Cycloalkyl-2-Imidazole-Imidazole) Cycloalkylmethyl) and Related Compounds ". Compounds of Formula (I): where X is S and the variables have the meaning as defined in the specification, are specific or selective for alpha-2B ~ and / or alpha-2C ~ adrenergic receptors rather than alpha-2A ~ adrenergic receptors, and as such have no or only minimal cardiovascular and / or sedative activity. These compounds of Formula (I) are useful as medicaments in mammals, including humans, for the treatment of diseases and / or relief from conditions that are sensitive to treatment by alpha-2B-adrenergic receptor agonists. The compounds of Formula (I) where X is O also have the advantageous property that they have no or only minimal cardiovascular and / or sedative activity and are useful for treating pain and other conditions with no or only minimal cardiovascular and / or activity. sedative.