Aryl {4-halogen-4 (heteroaryl methylamino) methyl piperidin-1-yl} methanone derivatives, their preparation process and their use as medicines

摘要

"Aryl- {4-halogen-4 - [(hetero-arylmethylamino) -methyl] -PI peridin-1-yl) -methanone derivatives, their process for preparation and their use as medicines". The present invention relates to compounds of formula (1) wherein X and Y represent a carbon atom bonded to a hydrogen (CH) atom or a nitrogen atom; A represents a methyl, fluoromethyl, cyano, hydroxyl, methoxyl radical, a chlorine atom or a fluorine atom with the proviso, however, that when A is a methyl radical (CH ~ 3 ~), and X and Y represent simultaneously a carbon atom attached to a hydrogen atom, then B necessarily represents a chlorine atom; B represents a chlorine atom or a fluorine atom; D represents a hydrogen atom, a chlorine atom, a fluorine atom, a cyano group or a trifluoromethyl group; E represents a hydrogen, fluorine or chlorine atom.