A compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, and methods for inhibiting the activity of the dipeptidyl peptidase-iv enzyme in a mammal in need thereof, to treat diabetes in a mammal in need thereof, to treat non-insulin dependent diabetes (type 2). 2) in a mammal in need of it, to treat hyperglycemia in a mammal in need of it, to treat obesity in a mammal in need of it, to treat one or more lipid disorders selected from the group of dyslipidemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolaemia, low hdl and high ldl in a mammal in need of it, and to treat in a mammal in need of one or more conditions

摘要

"COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT OF THIS PHARMACEUTICAL COMPOSITION, AND, METHODS FOR INHIBITING THE ACTIVITY OF THE DIPEPTIDIL PEPTIDASE-IV ENZYME, TO TREAT DIABETES IN A NESTEIN DIFFERE, TYPE 2) IN A MAMMER IN NEED OF THIS, TO TREAT HYPERGLYCEMIA IN A MAMMER IN THIS NEED TO TREAT OBESITY IN A NEED OF THIS, TO TREAT ONE OR MORE SELECTED LIPID HYPERDIA LIPID DYPERS, LOW HDL AND HIGH LDL IN A MAMMER IN NEED OF THIS, AND TO TREAT IN A MAMMER IN THIS ONE OR MORE CONDITIONS ". The present invention is directed to compounds which are dipeptidyl peptidase-IV enzyme inhibitors ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which dipeptidyl peptidase-IV enzyme is involved, such as diabetes. and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.