Processes for preparing a perindopril salt, perindopril t-butylamine, a pharmaceutically acceptable salt perindopril monohydrate, products obtained and their use

摘要

"PROCESSES FOR PREPARING PERINDOPRIL SALT, PERINDOPRIL T-BUTYLAMINE, A PHARMACEUTICALLY ACCEPTABLE SALT PERINDOPRIL, PRODUCTS OBTAINED AND THEIR USE". A process for preparing a pharmaceutically acceptable perindopril salt of formula (I) from a protected precursor compound of formula (II) wherein R represents a carboxyl protecting group. The process according to the invention comprises subjecting a compound of formula (II) to deprotection of the COOR carboxylic group attached to the heterocyclic ring to produce the corresponding free acid, which deprotection being performed in the presence of a base which forms a pharmaceutically salt. acceptable with said free acid formed by said deprotection. Also described is the preparation of a pharmaceutically acceptable perindopril salt monohydrate in addition to its use.