Preparation method of quinapril hydrochloride by reaction between a 2.5 - - oxazolidin and an ester of a terbutilico Tetrahydro Isoquinoline,Useful as active Principle for the treatment of hypertension and congestive heart failure

摘要

Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester to yield quinapril tert-butyl ester, which is subsequently reacted with an acid to yield quinapril or an acid addition salt of quinapril.