Liquid formulation comprising a Protein or Antibody in amount of 100 to 260 mg / ml arginine HCl in amount of 50 to 200 mm histidine in amount of 10 to 100 mm, Polysorbate quantity 0.01 to 0.1, pH between 5.5 and 7.0, viscosity Cinetic

摘要

The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and methods for using them to treat disorders treatable by the formulated antibody or protein. The formulations comprise arginine-HCl, histidine and polysorbate.