Interleukin-1 inhibitor - obtd. from urine of febrile patients or by recombinant DNA techniques, used in immunosuppressive and anti-inflammatory compsns.

摘要

A pure interleukin-1 inhibitor (IL-1 INH) is claimed characterised by an inhibitory activity to the LAF activity of IL-1, to the MCF activity of IL-1, to IL-1 mediated fibroblast proliferation and non-inhibitory activity to the INF alpha mediated prodn. of PGE2 and collagenase. Also claimed is a recombient DNa molecule comprising a DNA sequence which codes on expression for the IL-1 INH.