Assessment of allelic variation in terms of trans-acting factors

摘要

PCT No. PCT/AU93/00394 Sec. 371 Date Mar. 2, 1995 Sec. 102(e) Date Mar. 2, 1995 PCT Filed Aug. 2, 1993 PCT Pub. No. WO94/03633 PCT Pub. Date Feb. 17, 1994The present invention provides a genetic test for assaying predisposition to and/or resistance to high rates of bone turnover, development of low bone mass and responsiveness or otherwise to therapeutic modalities. This is a specific model for use in prediction of osteoporosis and likely response to preventive or therapeutic modalities. It is a general model of allelic variation in transcriptional regulators determining physiological set-points and thus susceptibility or resistance to certain pathophysiological states.