AZABICYCLIC, AZATRICYCLIC AND AZASPYROCYCLIC DERIVATIVES OF AMINOCYCLOGEXANE AS ANTAGONISTS OF NMDA, 5HT RECEPTORS AND NEURAL NICOTINE RECEPTORS

摘要

Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes of the formula 1 (N, Y, Z, R, R-R-R have the values indicated in the claims), which are systemically acting as antagonists of NMDA receptors and 5HT and nicotinic receptors, pharmaceutical compositions containing them are proposed. , method for their preparation and method for treating disorders of the central nervous system, which include disorders of glutamatergic, serotonergic and nicotine transmission, and treatment of immunomodulatory disorders, as well as disorders that can a means to treat with anti-malaria and antitripanosomnoy activity, antiviral activity (against the virus Borna), with the action against the virus (herpes simplex virus HSV) and activity against HBV C.Mezhdunarodnaya application was published together with the international search report.