PROCESS FOR AQUEOUS GRANULATION OF A MACROLIDE ANTIBIOTIC, PHARMACEUTICAL GRANULES PREPARED ACCORDING TO THE PROCESS AND A METHOD FOR INCREASING THE HARDNESS OF SUCH PHARMACEUTICAL GRANULES

摘要

The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.