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USE OF A DELETION VARIANT HUMAN t-PA PROTEIN IN THE PREPARATION OF A MEDICAMENT FOR TREATMENT OF VASCULAR DISEASES
USE OF A DELETION VARIANT HUMAN t-PA PROTEIN IN THE PREPARATION OF A MEDICAMENT FOR TREATMENT OF VASCULAR DISEASES
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机译:缺失的人类t-PA蛋白在制备治疗血管性疾病的药物中的用途
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摘要
Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
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