首页> 外国专利> 5 - {4 - 2 - (N - METHYL - N - (2 - PYRIDYL) AMINO) ETHOXY BENZYL} - 5 {1 - 2, 4 -DIOXOTHIAZOLIDINE - 5 - YL - 1 - 4 - (2 -(N - METHYL - N - (2 - PYRIDYL) AMINO) ETHOXY) PHENYL METHYL} - 2, 4 THIAZOLIDINEDIONE AND TAUTOMERIC, SALT OR SOLVATE THEREOF

5 - {4 - 2 - (N - METHYL - N - (2 - PYRIDYL) AMINO) ETHOXY BENZYL} - 5 {1 - 2, 4 -DIOXOTHIAZOLIDINE - 5 - YL - 1 - 4 - (2 -(N - METHYL - N - (2 - PYRIDYL) AMINO) ETHOXY) PHENYL METHYL} - 2, 4 THIAZOLIDINEDIONE AND TAUTOMERIC, SALT OR SOLVATE THEREOF

机译:5-{4-[2--(N-甲基-N-(2-吡啶基)氨基)乙氧基]苯}}-5 {1-[2,4-二氧噻唑啉-5-YL]-1-[4-(2 -(N-甲基-N-(2-吡啶基)氨基)乙氧基)苯基]甲基}-2,4噻唑烷二酮及其牛磺酸,盐或溶剂化物

摘要

A process for preparing a compound of formula (I, I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, wherein: J represents O or S; T represents a substituted or unsubstituted aryl group and T1 is O or S; which process comprises reducing a compound of formula (II, II) or a tautomeric form thereof or a salt thereof or a solvate thereof, wherein T and T1 are as defined in relation to formula (I), with a complex hydride reducing agent or a source of a complex hydride reducing agent; and thereafter, as required, preparing a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof.
机译:制备式(I,I)化合物或其互变异构形式或其可药用盐或其可药用溶剂化物的方法,其中:J表示O或S; T代表取代或未取代的芳基,T1为O或S;该方法包括用络合的氢化物还原剂或氢化物还原式(II,II)的化合物或其互变异构形式或其盐或其溶剂化物,其中T和T1如对式(I)所定义。复合氢化物还原剂的来源;然后根据需要制备式(I)化合物或其互变异构形式的可药用盐或可药用溶剂化物。

著录项

  • 公开/公告号IL166189B

    专利类型

  • 公开/公告日2005-07-25

    原文格式PDF

  • 申请/专利权人 SMITHKLINE BEECHAM PLC;

    申请/专利号IL166189

  • 发明设计人

    申请日2005-01-06

  • 分类号

  • 国家 IL

  • 入库时间 2022-08-21 22:17:48

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