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OBTENTION AND SYNTHESIS OF NEUTRAL PORPHYRINYL-NUCLEOTIDES, THE APPLICATION AS PRO-DRUGS AND USE THEREOF AS ANTICANCER AND ANTIVIRAL AGENTS.
OBTENTION AND SYNTHESIS OF NEUTRAL PORPHYRINYL-NUCLEOTIDES, THE APPLICATION AS PRO-DRUGS AND USE THEREOF AS ANTICANCER AND ANTIVIRAL AGENTS.
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机译:中性卟啉核苷的合成与合成,作为前体药物的用途以及用作抗癌剂和抗病毒剂的用途。
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摘要
The invention describes neutral porphyrinyl-nucleotides as pro-drugs, which selectively transport nucleosides with therapeutic activity to tumour cells or cells infected by a virus. The porphyrinyl-nucleotides contain phosphate, phosphoramidate or thiophosphate bonds, which enable one or several identical molecules of the nucleoside analogue in question or a combination of different nucleoside molecules to be joined together. Moreover the invention provides novel porphyrins having anti-tumour and/or antiviral activity useful both in photodynamic therapy by themselves, or as carriers of nucleoside analogues so that pro-drugs can be obtained.
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