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PHARMACEUTICAL COMPOSITIONS IN AEROSOL CONTAINING SALBUTAMOL IN AN AQUEOUS SOLUTION, AND IMPROVED PROCESS FOR PACKAGING PHARMACEUTICAL COMPOSITIONS IN AEROSOL.
PHARMACEUTICAL COMPOSITIONS IN AEROSOL CONTAINING SALBUTAMOL IN AN AQUEOUS SOLUTION, AND IMPROVED PROCESS FOR PACKAGING PHARMACEUTICAL COMPOSITIONS IN AEROSOL.
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机译:包含沙丁胺醇的水溶液中的药物成分,以及用于包装药物成分的改进工艺。
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摘要
The present invention refers to aerosol formulations for administering drugs, more particularly, salbutamol by inhalation. The invention provides novel aerosol formulations comprising (a) Salbutamol, (b) a polar co-solvent and (c) a hydrofluorocarbon (HFC) or hydrofluoroalkane (HFA) propellant. The formulation is characterized in that it is chlorofluorocarbon (CFC) propellant-free, containing the drug completely solubilized therein, which facilitates the absorption of the active principle by the airways; the invention ensures the uniformity of the doses administered in each shot and promotes the physical stability of the final formulation. The invention is further characterized in that the salbutamol is drug-free and the formula is contained in a suitable aluminium container, which does not have any inner coating. The present invention includes a non-conventional manufacturing method useful for dispensing the components of the formula without requiring freezing or especial environment al conditions, the same being practically, quickly and easily operated as especial cooling fittings are not required, the dispensing action can be adjusted during the process. Said method is more cost effective since an additional energy consumption is not required, and has the same advantages of the conventional filling method under cooling.
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