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USE OF TRANSTHYRETIN PEPTIDE/PROTEIN FUSIONS TO INCREASE THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE PEPTIDES/PROTEINS.
USE OF TRANSTHYRETIN PEPTIDE/PROTEIN FUSIONS TO INCREASE THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE PEPTIDES/PROTEINS.
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机译:使用促甲状腺素肽/蛋白质融合剂增加药理活性肽/蛋白质的血清半衰期。
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摘要
The present invention provides a means for increasing the serum half-life of a selected biologically active agent by utilizing transthyretin (TTR) as a fusion partner with a biologically active agent. Specifically, the present invention provides substantially homogenous preparations of TTR (or a TTR variant)-biologically active agent fusions and PEG-TTR (PEG-TTR variant)-biologically active agent fusions. As compared to the biologically active agent alone, the TTR-biologically active agent fusion and/or PEG-TTR-biologically active agent fusion has substantially increased serum half-life.
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