PROCESS FOR PREPARING 5-((R) -2-(5, 6-DIETHYL -INDIAN-2 -YLAMINO)-1- HYDROXY- ETHYL)-8 -HYDROXY- (1H)-QUINOLIN -2-ONE SALT, USEFUL AS AN ADRENOCEPTOR AGONIST.

摘要

A process for preparing 5-[(R)-2 -(5, 6-diethyl-indan -2-ylamino)- 1-hydroxy-ethyl] -8-hydroxy- (1H)-quinolin-2 -one salt. The process involves forming an acid salt of 5-[(R)- 2-(5, 6-diethyl-indan -2-ylamino)- 1-hydroxy- ethyl]-8- substituted oxy- (1 H)-quinolin- 2 -one (V); and converting the acid salt to a salt of 5- [(R)-2-(5, 6-diethyl- indan-2- ylamino)-1 -hydroxy-ethyl] -8-hydroxy- (1H)-quinolin -2-one (VI) without isolating the free base of 5-[(R) -2-(5, 6-diethyl -indan- 2-ylamino) -1-hydroxy -ethyl] -8-hydroxy-(1H) -quinolin -2-one. Formula (A); (V): R = a protecting group, (VI): R = H.