Compounds 3 - (pyridin-2-yl) - 4 - substituted heteroaryl pyrazole,Aik5 antagonists and / or aik4; Pharmaceutical Composition and use of the compound in the treatment of fibrotic disorders like scleroderma, lupus nephritis, healing with instructions

摘要

The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).