Lysostaphin is demonstrated to be a powerful anti-staphylococcal agent suitable for parenteral administration to mammals including humans. Low dosages, in the order of 0.5 - 45 mg/kg/day are sufficient to eradicate most staphylococcal infections. Lysostaphin is also effective against bacteria of this type that have developed resistance to conventional antibiotics such as penicillins and vancomycin. Lysostaphin analogues, such as variants and related enzymes, show similar activity. The figure shows a graph reflecting the bactericidal activity of lysostaphin against a variety of S. aureus strains of differing antimicrobial resistance. These data demonstrate that lysostaphin has potent and rapid bactericidal activity against contemporary clinical isolates of S. aureus, including strains resistant to methicillin and strains both resistant to methicillin and intermediately resistant to vancomycin.
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机译:溶葡萄球菌素是一种强大的抗葡萄球菌药物,适用于肠胃外给药给包括人类在内的哺乳动物。低剂量(约0.5-45 mg / kg /天)足以根除大多数葡萄球菌感染。溶葡萄球菌素还对这种对常规抗生素如青霉素和万古霉素产生耐药性的细菌有效。溶葡萄球菌素类似物,例如变体和相关酶,显示出相似的活性。该图显示了反映溶葡萄球菌素对多种具有不同抗微生物性的金黄色葡萄球菌菌株的杀菌活性的图。这些数据表明,溶葡萄球菌素对当代金黄色葡萄球菌临床分离株具有有效且快速的杀菌活性,包括对甲氧西林有抗性的菌株以及对甲氧西林有抗性和对万古霉素具有中度抗性的菌株。
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