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Glycine-substituted thieno 2,3-dpyrimidines with combined LH and FSH agonistic activity may be used to treat fertility disorders
Glycine-substituted thieno 2,3-dpyrimidines with combined LH and FSH agonistic activity may be used to treat fertility disorders
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机译:具有LH和FSH联合激动活性的甘氨酸取代的噻吩并[2,3-d]嘧啶可用于治疗生育障碍
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摘要
Describes a thieno derivative according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein: X is O or H,H; A is S, NH, N(R6), O or a bond; R1 is alkyl, alkenyl, phenyl or heteroaryl, the phenyl or heteroaryl ring optionally being substituted with one or more of the group of substituents: hydroxy, halogen, nitro, trifluoromethyl, cyano, amino or (di)alkylamino; R2 is H, alkyl, alkoxyalkyl or hydroxyalkyl; R3 and R4 can be independently selected from H, alkyl and hydroxyalkyl; R5 is H or alkyl, and can be selected from the same groups as described for R1. The compounds described have LH as well as FSH receptor activating activity and can be used in fertility regulating therapies.
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