Heterocyclic aromatic compounds on the growth hormone secretagogues

摘要

Refers to a compound of formula I, where Xa is 2-4 Rings Spiro FUSED heteroaryl, aryl, Heterocyclic, among others; r1 is alkyl, aryl, alquenilo, arylalkyl, among others; R2, R3 and R4 are each alquenilo h, alkyl, cycloalkyl, aryl, R1, among others; 'is H, alkyl, cicloal Chilo heteroaryl, among others; and it is alquileno, alquenileno, arylene, among others; Z is n; n is 1 - 6.Preferred compounds are: 2 - amino - N - [2 - (6 - bromo - [1,2,4] triazolo [4,3-a] pyridin-3-yl) - propyl] - phenyl - 3 - methyl - 2 - propionamide; 2 - amino - 2 - methyl - N - phenyl - 3 - [1 - (6 - trifluoromethyl - [1,2,4] triazolo [4,3-a] pyridin-3-yl) - propyl] - propionamide; among others. It also relates to a Pharmaceutical composition useful for the treatment of Obesity, osteoporosis and in improving muscle mass and strength