Azabiciclos substituted Derivatives of piridiloximetilo and bencisoxazol

摘要

Refers to azabiciclicos piridiloximetilo and bencisoxasol Derivatives of formula I, where M is 0 - 1; Z is C (o) - CH2 - R7, R8, among others; where H is R7, R8 is C1 - C3 alkoxy; h, Oh, C1 and C3 alkoxy; methylene is where n is 0 - 2; R1 and R2 is H, alkyl, Halo, C1 - C6 C1 - C6; alkoxy; R3 and R4 are h, alkyl - C1 C3 - C7 C6; Heterocyclic cycloalkyl Group of 5 to 6 members,Among others; R3 and R4 n that are attached together to form a Ring monociclico optionally unsaturated 3 to 7 members, among others.Preferred compounds are (7R, 9aS) - trans - 2 - benzo [d] isoxazole - 3 - il - 7 - (4 - (4 - 1 - methyl - 2 - pyridin - iloximetil) - - - octahidro pirido [1,2-a] pyrazine (7R, 9aS) - trans - 2 - benzo [d] isoxazole - il - 7 - 3 - (5 - piperidin-1-ylmethyl pyridin 2 - - - - - - iloximetil) octahidro pirido [1,2-a] pyrazine (7R, 9aS, trans) - 2 - (5 - fluoro - benzo [d] isoxazole - 3 - yl) - 7 - (5) - pyrrolidin-3-yl pyridin - 1 - methyl - 2 - - - - - iloximetil) octahidro pirido [1,2-a] pyrazine.Among others. It also relates to a Pharmaceutical composition. These compounds inhibit the 5 - receptors 5-ht1b 5-ht2a and D2, and are useful for treating one or more central nervous system Disorders such as Schizophrenia and Depression