首页> 外国专利> 6-acetyl-8-cyclopentyl-5-methyl-2 - (5-piperazin-1-il-piridin-2-ilamino) - 8-pirido 2,3-d pirimidin-7-ona as a selective inhibitor of CDK4

6-acetyl-8-cyclopentyl-5-methyl-2 - (5-piperazin-1-il-piridin-2-ilamino) - 8-pirido 2,3-d pirimidin-7-ona as a selective inhibitor of CDK4

机译:6-乙酰基-8-环戊基-5-甲基-2--(5-哌嗪-1-基-哌啶-2-基氨基)-8-吡啶酮[2,3-d]派瑞密-7-ona作为选择性抑制剂CDK4

摘要

It refers to a monomer salt of 6-ethyl-8-cyclopentanediol-5-methyl-2 - (5-piperazin-1-piridin-2-ilamino) - 8h pirido [2, 3-d] pirimidin-7-ona, which can be expressed as a, B and D-shaped polymorphs, each of which can be distinguished by its PXRD, Raman spectrum and DSC thermoelectric diagram. It also refers to a method for preparing Aldrin salt, including combining an Aldrin solution and a first solvent with a water mixture of the compound to produce a first mixture,It also includes liofilization of the mixture in order to produce an amoxic salt, which is then combined with a second solvent to produce a second mixture, including crystallized Aldrin salts, and optionally heated and / or cooled, the first and second solvents may be the same, which can be dissolved as methanol in water, Ethanol or other alcohol. It also refers to the pharmacological components containing these substances, which are a selective quinase inhibitor, dependent on cyclohexane-4 (CDK4), and an effective means to treat inflammation and abnormal cell proliferation such as cancer and recurrence.
机译:它是指6-乙基-8-环戊二醇-5-甲基-2-(5-哌嗪-1-哌啶-2-基氨基)-8h吡啶基[2,3-d]嘧啶-7-ona的单体盐可以表示为a,B和D形的多晶型物,它们的每一个都可以通过其PXRD,拉曼光谱和DSC热电图来区分。它还涉及制备艾氏剂盐的方法,包括将艾氏剂溶液和第一溶剂与该化合物的水混合物混合以产生第一混合物,还包括将混合物进行微孔化以制备一氧化铁盐,该方法为然后与第二溶剂混合以产生第二混合物,包括结晶的艾德林盐,并任选加热和/或冷却,第一和第二溶剂可以相同,可以作为甲醇溶于水,乙醇或其他醇中。它还指的是含有这些物质的药理成分,它们是依赖环己烷-4(CDK4)的选择性奎纳酶抑制剂,是治疗炎症和异常细胞增殖(如癌症和复发)的有效手段。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号