C-4 CARBONATE TAXES

摘要

The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations.The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease.in which:R is phenyl, isopropyl, or tert butyl;R1 is -C(O)Rz in which Rz is (CH3)3CO-, (CH3)3CCH2-, CH3(CH2)3O-, cyclobutyl-, cyclohexyloxy, or (2-furyl);R2 is CH3C(O)O-.