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IDENTIFICATION OF HUMAN CITOMEGALOVIRUS GENES INVOLVED IN THE NEGATIVE ADJUSTMENT OF MHC HEAVY CHAIN EXPRESSION CLASS I
IDENTIFICATION OF HUMAN CITOMEGALOVIRUS GENES INVOLVED IN THE NEGATIVE ADJUSTMENT OF MHC HEAVY CHAIN EXPRESSION CLASS I
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机译:否定调节MHC重链表达I类涉及的人类巨结肠病毒基因
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摘要
The human cytomegalovirus (HCMV) genomic US region encodes a family of homologous genes essential for the inhibition of major histocompatiblity complex (MHC) class I mediated antigen presentation observed during viral infection. Here we show that US3 and US6 encode ER-resident glycoproteins that prevent intracellular transport of NMC class I molecules by different mechanisms. US3 retains stable MHC class I heterodimers in the ER which are loaded with peptides while retained in the ER. US6 prevents MHC class I assembly with beta 2 microglobulin which results in free heavy chains leaving the ER. These genes have the potential to prevent unwanted immunological reactivities triggered by MHC class I molecules.
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