MONOCLONAL ANTIBODY AGGLUTINATING SPERM SURFACE GLYCOPROTEIN SAGA-1, ANTIGEN DETECTED BY THIS ANTIBODY, VACCINE AND SPERMICIDE CONTAINING THIS ANTIGEN

摘要

The monoclonal antibody (S19), expressed by hybridoma (access number HB 12144, ATCC), effectively agglutinates a sperm surface glycoprotein, SAGA-1 protein. The mAB finds utility as a binding agent in a spermicide, showing a high degree of effectiveness in binding potential sperm. The protein bound,identified as SAGA-1, is the immunogen in a contraceptive vaccine, as well as the standard for determining antibody titer upon vaccination. The monoclonal antibody can also be used as a diagnostic to determine the presence, and amount, of sperm in a variety of samples.