Antagonists of the transcription factor c-maf Short Form for the treatment of glaucoma

摘要

The form of the shortened version of facator c-maf Transcription is up regulated in the trabecular meshwork cells treated with steroids or treated with transforming growth factor beta, and is present in niveleselevados normal trabecular meshwork cells against the affected by G Laucoma and Brain tissue of normal and glaucomatous optic nerve.The expression of the transcription factor c-maf Short Form under these Conditions indicates a role for the effector or causal factor in the Pathogenesis of Primary open-angle glaucoma or induced by steroids.The antagonism of the expression or activity of the transcription factor c-maf Short Form in the trabecular meshwork or other ocular Tissue is provided to inhibit or alleviate the Pathogenesis of glaucoma. Antagonists include inhibitors of Cyclin Dependent Kinase 2.