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PSEUDO SEMI-NODE TRAINING RNA BY HYBRIDIZING ANTISE SEOLIGON NUCLEOTIDS ON TARGETED RNA SECONDARY STRUCTURES
PSEUDO SEMI-NODE TRAINING RNA BY HYBRIDIZING ANTISE SEOLIGON NUCLEOTIDS ON TARGETED RNA SECONDARY STRUCTURES
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机译:通过在目标RNA二级结构上杂交抗曲蛋白核糖核苷酸来假核半RNA训练RNA
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摘要
Compositions and methods for modulating the activity of RNA are provided. Oligonucleotides are hybridized with an RNA structure to form a stable heteroduplex so that the RNA is no longer recognized by its regulatory protein after oligonucleotide binding. Reactive moieties can be tethered to the oligonucleotide that enhance its activity. Antisense oligonucleotides directed against HIV TAR are provided.
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