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THE ANTI-GENOME OF NON-SEGMENTED MINUSES RNA viruses corresponding to CDNA and methods for producing such viruses which additionally code antigenically active proteins
THE ANTI-GENOME OF NON-SEGMENTED MINUSES RNA viruses corresponding to CDNA and methods for producing such viruses which additionally code antigenically active proteins
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机译:不分节段的反基因组对应于CDNA的RNA病毒及其生产方法,它们还编码抗原活性蛋白
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摘要
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae. IMAGE
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