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BY PHENYL PROSTAGLANDINE E-DERIVATIVES SUBSTITUTED BY AN OMEGA-THIAREST, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE INGREDIENT
BY PHENYL PROSTAGLANDINE E-DERIVATIVES SUBSTITUTED BY AN OMEGA-THIAREST, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE INGREDIENT
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机译:由奥米伽-噻吩酯取代的苯前列腺素电子衍生物,其制备方法和包含其为有效成分的药物
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摘要
5-Thia- omega -substituted phenyl-prostaglandin E derivatives represented by general formula (I) wherein each symbol is as defined in the specification. Because of being capable of bonding strongly to PEG2receptors (in particular, the subtype EP4), the compounds represented by general formula (I) are expected as useful in preventing and/or treating immunologic diseases, asthma, bone dysplasia, nerve cell death, lung failure, hepatopathy, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory syndrome, ambustion pain, sepsis, hemophagous syndrome, macrophage activation syndrome, Still disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock, etc. Moreover, these compounds participate in sleep disorders and platelet aggregation and, therefore, are expected as useful in preventing/treating these diseases. CHEM
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