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MEDICAMENT CONTAINS AN EFFECTOR OF GLUTATHIONMETABOLISM (AMBROXOL) TOGETHER WITH ALPHA-LIPONIC ACID IN THE CONTEXT OF THE TREATMENT OF DIABETES MELLITUS
MEDICAMENT CONTAINS AN EFFECTOR OF GLUTATHIONMETABOLISM (AMBROXOL) TOGETHER WITH ALPHA-LIPONIC ACID IN THE CONTEXT OF THE TREATMENT OF DIABETES MELLITUS
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机译:在糖尿病治疗的背景下,药物与谷胱甘肽代谢(ambroxol)一起含有α-脂肪酸
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摘要
A new medicament (A) for treating thiol-disulfide status disorders in diabetes mellitus comprises a glutathione metabolism effector (I) and alpha -lipoic acid (II) (both optionally in salt and/or prodrug form), as a combination preparation for simultaneous, separate or successive administration. Independent claims are also included for the use of (I) together with (II) for the preparation of a medicament for treating thiol-disulfide status disorders, as immunomodulator and/or defense mechanism stimulant or as antiinflammatory agent, all for combating diabetes mellitus. ACTIVITY : Antidiabetic; Immunomodulator; Antiinflammatory. MECHANISM OF ACTION : Thiol-disulfide status regulator; glutathione metabolism effector; Angiotensin converting enzyme (ACE) inhibitor; Antioxidant; Free radical scavenger. When peripheral immune cells were cultured under thiol-deficient conditions, optionally in presence of captopril (Ia) and/or (II), the intracellular thiol expression (in mfi(Beads/Ratio)) (initially 2.88) after 14 days was 0.65 in controls (without addition of (Ia) or (II)), 1.83 in presence of 50 MicroM (II), 0.75 in presence of 10 MicroM (Ia) or 2.86 in presence of 50 MicroM (II) plus 10 MicroM (Ia).
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