TRANSGENIC NON-HUMAN MAMPHERS AS MODELS FOR HUMAN PATHOLOGIES WITH ORIGIN IN STEM CELLS.

摘要

Transgenic non-human mammals that reproduce the human pathology that originates in stem cells, for example, chromosomal abnormalities associated with chronic myeloid leukemia, acute lymphoblastic leukemia of strain B, acute lymphoblastic leukemia of strain T, or the migration of hematopoietic stem cells or embryonic, using as a strategy the expression of the genes involved in said pathology in humans through a promoter that directs the expression of a transgene in Sca-1 + cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds useful for the treatment and / or prevention of said diseases.