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METHOD FOR THE PRODUCTION OF L-CARNITINE FROM CROTONOBETAINE, D-CARNITINE AND THE SALTS AND DERIVATIVES THEREOF, USING PERMEABILISED CELLS OF PROTEUS SP. OR ESCHERICHIA COLI
METHOD FOR THE PRODUCTION OF L-CARNITINE FROM CROTONOBETAINE, D-CARNITINE AND THE SALTS AND DERIVATIVES THEREOF, USING PERMEABILISED CELLS OF PROTEUS SP. OR ESCHERICHIA COLI
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机译:使用巴氏蛋白酶SP的透化细胞从巴豆糖碱,D-肉碱及其盐生产L-肉碱的方法及其衍生物或大肠杆菌
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摘要
The invention relates to a method for the production of L-carnitine from a biotransformation substrate that is selected from crotonobetaine, a salt of crotonobetaine, a derivative of crotonobetaine, D-carnitine, a salt of D-carnitine and mixtures of same. The inventive method consists in cultivating free or immobilised permeabilised cells of Escherichia coli or Proteus sp. in a culture medium containing the aforementioned biotransformation substrate and the necessary nutrients in order to maintain the viability of said cells, under conditions that enable the production of L-carnitine. The above-mentioned culture medium can contain compounds that activate the growth of said cells and/or compounds that induce the enzymes involved in the metabolism of L-carnitine and/or compounds that inhibit the transformation of crotonobetaine into gamma-butyrobetaine.
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