首页> 外国专利> USE OF CHOLINESTERASE INHIBITORS TO COMBAT LACK OF ATTENTION DISORDERS.

USE OF CHOLINESTERASE INHIBITORS TO COMBAT LACK OF ATTENTION DISORDERS.

机译:使用胆碱酯酶抑制剂来应对注意力不集中的情况。

摘要

Use of galantamine or a derivative thereof of ** formula ** in which the dashed line represents a double bond optionally present between carbon atoms 3 and 4, each R1 is independently selected from among the members of the group consisting hydrogen, hydroxyl, straight or branched chain alkyl, hydroxyalkyl, carboxyalkylamino, alkylamino, acyl, lower alkanoyl, cyano, sulfhydryl, C1-6 alkoxy, alkylthio, aryloxy, arylthio, R3-substituted aryloxy, R3-substituted arylthio, aralkoxy , an optionally R3-substituted aryl or aliphatic carbamyl group, aralkylthio, R3-substituted aralkoxy, R3-substituted aralkylthio, aryloxymethyl, R3-substituted aryloxymethyl, alkanoyloxy, hydroxy-substituted alkanoyloxy, benzoyloxy, R3-carbonyl and aryloxycarbonyl, aryloxycarbonyl substituted, R2 is selected from among the members of the group consisting of hydrogen, straight or branched C1-6 alkyl, an alkenyl or alkaryl group, optionally entity substituted by a halogen atom or a cycloalkyl, hydroxy, alkoxy, nitro, amino, aminoalkyl, acylamino, heteroaryl, heteroaryl-alkyl, aryl, arylalkyl, cyano, amyl, aroyl, cycloalkylmethyl, allyl, phenyl, R3-substituted phenyl, alkylphenyl, R3-substituted alkylphenyl, heterocyclyl selected from the members of the group consisting of a- or a-furyl, a- or a-thienyl, tenyl, pyridyl, pyrazinyl and pyrimidyl, alkyl-heterocyclyl or heterocyclyl R '' - substituted , where R '' is alkyl or alkoxy.
机译:使用加兰他敏或其**式**的衍生物,其中虚线表示碳原子3和4之间任选存在的双键,每个R 1独立地选自氢,羟基,直链或直链的组中的成员支链烷基,羟烷基,羧烷基氨基,烷基氨基,酰基,低级烷酰基,氰基,巯基,C 1-6烷氧基,烷硫基,芳氧基,芳硫基,R 3取代的芳氧基,R 3取代的芳硫基,芳烷氧基,任选地R 3取代的芳基或脂族基氨基甲酰基,芳烷硫基,R 3取代的芳烷氧基,R 3取代的芳烷硫基,芳氧基甲基,R 3取代的芳氧基甲基,链烷酰氧基,羟基取代的烷酰氧基,苯甲酰氧基,R 3羰基和芳氧基羰基,芳氧基羰基取代,R 2选自基团由氢,直链或支链C1-6烷基,烯基或烷芳基组成,可选地被卤素原子或环烷基,羟基,烷氧基,硝基取代的实体邻,氨基,氨基烷基,酰基氨基,杂芳基,杂芳基-烷基,芳基,芳基烷基,氰基,戊基,芳酰基,环烷基甲基,烯丙基,苯基,R 3-取代的苯基,烷基苯基,R 3-取代的烷基苯基,选自基团的杂环基由α-或α-呋喃基,α-或α-噻吩基,丁基,吡啶基,吡嗪基和嘧啶基,烷基-杂环基或杂环基R”-取代组成,其中R”为烷基或烷氧基。

著录项

  • 公开/公告号ES2224421T3

    专利类型

  • 公开/公告日2005-03-01

    原文格式PDF

  • 申请/专利权人 SNORRASON ERNIR;

    申请/专利号ES19980938759T

  • 发明设计人 SNORRASON ERNIR;MURRAY JAMES ROBERT;

    申请日1998-08-07

  • 分类号A61K31/27;A61K31/66;A61K31/44;A61K31/4406;A61K31/40;A61K31/435;A61K31/55;A61P25/00;

  • 国家 ES

  • 入库时间 2022-08-21 22:14:51

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