FORMULATIONS FOR THE CONTROLLED AND PROLONGED RELEASE OF GM-CSF HAVE BEEN DEVELOPED. THESE FORMULATIONS ARE BASED ON SOLID MICROPARTICLES FORMED BY THE COMBINATION OF SYNTHETIC AND BIODEGRADABLE POLYMERS, AS THE POLYLACTIC ACID (PLA), THE POLYGLYCOLIC ACID (PGA) AND COPOLIMEROS OF THESE WITH EXCIPIENTS AND FARMACOLOGICAL ORGANIZED OR FIRST LOADS. , OR A MULTIPHASIC RELEASE IN AN APPROXIMATE PERIOD OF 3 TO 21 DAYS, PREFERIBLY ONE WEEK, BY ADMINISTERING THEM IN INJECTION. IN THE PREFERRED PRESENTATION, THE MICROPARTICLES ARE MICRO-SPHERES WITH DIAMETERS BETWEEN 10 AND 60 MICRONS, FORMED BY A PLUE MIXTURE WITH DIFFERENT MOLECULAR WEIGHTS, PREFERIBLY 6,000, 30,000 AND 41,000. OTHER PRESENTATIONS HAVE BEEN DEVELOPED TO MODIFY THE KINETICS OF LIBERATION OR THE DISTRIBUTION MODE OF THE IN VIVO FARMACO. FOR EXAMPLE, IN SOME CASES A POLYMER THAT PRODUCES A Slight INFLAMMATORY REACTION IS SELECTED, THE PEST AND THE POLYANHYDRATES CAN ACT AS CHEMICAL ATTRACTOR, DUE TO THE SAME POLYMER OR TO POLYMER CONTAINERS OR BIO-EMPOWERED BIO-EMPLOYERS. IN ANOTHER PRESENTATION GM-CSF IS MANAGED IN HYDROGEL THAT CAN BE INJECTED SUBCUTANEOUSLY OR IN A SPECIFIC AREA FOR CONTROLLED RELEASE. THE MICROPARTICLES OR HYDROGEL ARE ADMINISTERED TO THE PATIENT IN AN AMOUNT THAT IS EFFECTIVE TO STIMULATE THE PROLIFERATION OF HEMATOPOYETIC CELLS, ESPECIALLY LEUKOCYTES.
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