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NOVEL HIGH-TITRE RETROVIRAL VECTOR AND TRANSDUCTION METHODS
NOVEL HIGH-TITRE RETROVIRAL VECTOR AND TRANSDUCTION METHODS
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机译:新型高滴度逆转录病毒载体和转移方法
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摘要
The invention relates to a novel high-titre retroviral vector and transduction methods. More specifically, the invention relates to novel retroviral vectors that can produce high-titre, non-replicative, infectious retroviral particles and to methods of using said particles for the transfer of gene constructions of interest. In particular, the invention relates to retroviral vectors which are derived from MoMLV and which comprise a nucleotide sequence that is characterised by general formula: 5'-[CMV-R-U5]-[PBS]-[SD]-Psi+-[MCS2]-[SA]-[MCS]-[PPT]-[LTR]-3', as well as the uses of said vectors.
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