NEW DERIVATIVES OF TETRAHIDROBENZOINDOLONA.

摘要

THE INVENTION REFERS TO COMPOUNDS REPRESENTED BY THE FOLLOWING FORMULA (I), OR TO PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, AND TO A PROCEDURE FOR PRODUCING THEMSELVES. THESE COMPOUNDS PRESENT AN INHIBITORY ACTIVITY OF THE UNION TO THE PROGESTERONE RECEIVER AND, THEREFORE, CAN BE USED AS THERAPEUTIC AND PROFILACTIC AGENTS FOR DISEASES RELATED TO PROGESTERONE. SPECIFICALLY, THEY ARE USED AS CARCINOSTATIC AGENTS FOR CHEST AND OVARIAN CANCER, FOR HYSTEROMYOMA, ENDOMETRIOSIS, MENINGIOMA AND MYELOMA, ABORTION, ORAL CONTRACEPTIVE PILLERS AND THERAPORIES TO THERAPORIES. WHERE R 1 REPRESENTS RENT OR ARALQUILO; R 2 represents a hydrogen atom, ALQ UILCARBONILO, cycloalkylcarbonyl, aromatic acyl, acyl heteroaromatic, heterocyclic acyl SATURATED, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, carbamoyl AROMATIC, ARALQUILCARBAMOILO, alkylaminocarbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, thiocarbonyl heteroaromatic thiocarbonyl SATURATED HETEROCICLIC OR RENT - TIOCARBAMOIL; AND R 3 REPRESENTS A HYDROGEN ATOM, A HI DROXILO GROUP, ALQUILOXI, ALQUILCARBONILOXI, ALQUILTIO OR ARILTIO.