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USE OF POLYCLY 2-AMINOTIAZOL SYSTEMS FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF LIPOMETABOLIC DISORDERS, OBESITY AND TYPE II DIABETES.
USE OF POLYCLY 2-AMINOTIAZOL SYSTEMS FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF LIPOMETABOLIC DISORDERS, OBESITY AND TYPE II DIABETES.
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机译:聚合物2-氨基噻唑系统在制造治疗脂代谢紊乱,肥胖症和II型糖尿病的药物中的应用。
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摘要
Use of compounds of formula I, ** (Formula) ** in which Y means a direct bond; X means CH2; R1 means CF3, CN, COOH, COO (C1-C6 alkyl), CONH2, CONH (C1-C6 alkyl), CON (C1-C6 alkyl) 2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, O- (C1-C6 alkyl), one, several or all hydrogens of the alkyl, alkenyl and alkynyl radicals being replaced by fluorine; SO2-NH2, SO2NH (C1-C6 alkyl), SO2N (C1-C6 alkyl) 2, S- (C1-C6 alkyl), S- (CH2) n-phenyl, SO- (C1-C6 alkyl), SO- (CH2) n-phenyl, SO2- (C1-C6 alkyl), SO2- (CH2) n-phenyl, which may be n = 0-6, and the phenyl radical may be substituted up to twice with F, Cl, Br, OH, CF3, NO2, CN, OCF3, O- (C1-C6 alkyl), C1-C6 alkyl, NH2; phenyl, O-phenyl, the phenyl radical may be substituted up to three times with F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O- (C1-C6 alkyl), C1-C6 alkyl, NH2, NH (C1-C6 alkyl), N (C1-C6 alkyl) 2, SO2-CH3, COOH, COO- (C1-C6 alkyl), CONH2; Does R1 mean H, CF3, CN, COOH, COO (C1-C6 alkyl), CONH2, CONH (C1-C6 alkyl), CON (C1-C6 alkyl) 2, C1-C6 alkyl, C2-C6 alkenyl, C2 alkynyl -C6, O- (C1-C6 alkyl), one, several or all hydrogens of the alkyl, alkenyl and alkynyl radicals being replaced by fluorine; SO2-NH2, SO2NH (C1-C6 alkyl), SO2N (C1-C6 alkyl) 2, S- (C1-C6 alkyl), S- (CH2) n-phenyl, SO- (C1-C6 alkyl), SO- (CH2) n-phenyl, SO2- (C1-C6 alkyl), SO2- (CH2) n-phenyl, which may be n = 0-6, and the phenyl radical may be substituted up to twice with F, Cl, Br, OH, CF3, NO2, CN, OCF3, O- (C1-C6 alkyl), C1-C6 alkyl, NH2; phenyl, O-phenyl, the phenyl radical may be substituted up to three times with F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O- (C1-C6 alkyl), C1-C6 alkyl, NH2, NH (C1-C6 alkyl), N (C1-C6 alkyl) 2, SO2-CH3, COOH, COO- (C1-C6 alkyl), CONH2; R2 means NH2, NHR3, NR4R5; R3 means C1-C6 alkyl; R4 means C1-C6 alkyl; R5 means C1-C6 alkyl; and its physiologically acceptable salts, to prepare a medicament for treating metabolism disorders.
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