IMIDAZOLIDINE DERIVATIVES, ITS PREPARATION AND ITS USE AS AN ATTORNEY AGENT.

摘要

A compound of formula I, ** (Formula) ** in which A is cyclopropylmethyl or isobutyl; E is -CO-R6, -CO-H or -CH2-O-R7; Z is oxygen or sulfur; R1 is hydrogen or methyl; R2 is phenyl, pyridyl or (C1-C4) alkyl, where the alkyl moiety can be substituted with one or more fluorine atoms, and the phenyl moiety can be substituted with one or more equal or different substituents of the group consisting of alkyl ( C1-C4), (C1-C4) alkoxy, methylenedioxy, ethylenedioxy, halogen, trifluoromethyl and trifluoromethoxy; R3 and R4 are methyl or trifluoromethyl; R5 is hydrogen or (C1-C4) alkyl, where the alkyl moiety may be substituted with one or more fluorine atoms; R6 is hydroxyl, (C1-C10) alkoxy, phenyl-C1-C8 alkoxy, phenyloxy, (C1-C8) alkylcarbonyloxy-C1-C6 alkoxy, phenylcarbonyloxy-C1-C6 alkoxy, phenyl-alkyl (C1-C6) -carbonyloxy-alkoxy (C1-C6), alkoxy (C1-C8) -carbonyloxy-alkoxy (C1-C6), phenyloxy-carbonyloxy-alkoxy (C1-C6), phenyl-alkoxy (C1-C6) -carbonyloxy-C1-C6 alkoxy, amino, mono (C1-C10) alkyl-amino or di (C1-C10-alkyl) -amino; R7 is hydrogen or (C1-C4) alkyl; in all its stereoisomeric forms and mixtures in all proportions, or their physiologically tolerable salts.