METHOD OF TREATING HEART FAILURE WITH ENDOTHELIN ANTAGONISTS

摘要

The present invention is concerned with preventionand/or treatment of heart failure or ventricular dysfunctionwith compounds that are endothelin antagonists of theformula(see above formula)wherein Ar1 and Ar2 are an optionally substituted aromatic orheteroaromatic ring; R1, R2 and R3 are H, -OH or alkyl or R1and R2 or R2 and R3 together form a single bond; Y is -CO-R4(wherein R4 is -OH, -NH2, alkoxy, mono- or di-alkylamino,alkylsulfonylamino, arylsulfonylamino orarylalkylsulfonylamino), SO3H, PO3H2, tetrazolyl,2-oxo-3H-1,2,3,5-oxathiadiazolyl or 5-oxo-4H-1,2,4-oxadiazolyl; and Aforms together with the adjacent carbon-carbon double bond a5- or 6-membered optionally substituted heteroaromatic ring.