LOW MOLECULAR WEIGHT HEPARIN SALT WITH TRIETHANOLAMINE USEFUL AS THERAPEUTIC-ANTITROMBOTIC AGENT OF LOCAL DELIVERY, PROCEDURES FOR PREPARING THEM, PROCESS FOR ELIMINATION OF HYGROSCOPICITY OF HEPARIN SALT, PHARMACEUTICAL COMPOSITIONS FOR LOCAL USE IN ANTITHROMBOTIC THERAPY AND USES THEREIN

摘要

Low molecular weight heparin salt with triethanolamine useful as a therapeutic-antithrombotic agent for local delivery, having at least 60% of its total mass a molecular weight of less than 8000 Da and an average molecular weight from 4000 to 6000 Da, said salt also having a content of organic sulfur from 6.1 to 7,5 weight % (theoretical 6.8%) and a triethanolamine content from 42,6 to 52,1 weight % (theoretical 47,4 weight %). The processes for preparing the hepari n salt, eliminating hygroscopicity of said salt, and pharmaceutical compositions for use in local antithrombotic therapy and its uses are also disclosed.