FERROFLUIDS STABLE IN NEUTRAL MEDIA AND FERROFLUIDS MODIFIED OBTAINED BY MODIFYING THE MODIFYING OF SURFACE PARTICLES OF THESE FERROFLUIDS

摘要

the present invention relates to aqueous dispersions comprisingbased on the particle size of magnetic iron oxide, or lessup to 20 nm, and the surface is modified by the grafting of groupsr covalently bound amino on the surface of the particles, inthe isoelectric point and surface modified particlesgreater than or equal to 10. the invention also relates to a process ofpreparation of aqueous suspensions, as well as a process of changethe surface of the particles in the dispersion, in particularby immobilization of polysaccharides such as dextran, includingthe development of magnetic preparations administered in vivo, andinjectable compositions for the formulation of specific agentsin contrast for mri.