ANTIBODIES SPECIFIC FOR ACTIVATED CONFORMATION OF LFA-1

摘要

The disclosure provides, inter alia, binding proteins (e.g., antibodies) thatbind to an integrin in an activated conformation, e.g., activated LFA-1 (~aLFA-1~), e.g., relative to a non-activated conformation of LFA-1. In oneembodiment, the binding proteins inhibit at least one function of an aLFA-1,e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand ofaLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat orprevent an inflammatory disorder or other disorder.