Use of hydroxydiphenyl ether class of chemicals, as exemplified by triclosan, as an antimalarial and identification of fatty acid synthesis as its target

摘要

We report the use of hydroxydiphenyl ether class of chemicals, as exemplified by triclosan, (2,4,4'-trichloro-2'-hydroxydiphenyl ether), for both treatment and design of therapeutics for treatment of malaria. More specifically, the present invention relates to identification of fatty acid synthesis as target for this compound as well as a key enzyme involved in synthesizing them.