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PREVENTION OF SYSTEMIC TOXICITY DURING RADIOIMMUNOTHERAPY FOR INTRAVASCULARLY DISSEMINATED CANCERS
PREVENTION OF SYSTEMIC TOXICITY DURING RADIOIMMUNOTHERAPY FOR INTRAVASCULARLY DISSEMINATED CANCERS
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机译:预防血管内弥漫性癌症的放射免疫治疗中的系统毒性
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摘要
The present invention provides a method to target delivery of antibody constructs radiolabeled with an alpha-particle emitting radionuclide to intravascularly disseminated tumor cells while minimizing systemic toxicity. Targeted delivery of a construct specific for a protein expressed on the tumor cells in combination with rapid clearance of intravascular non-targeted radiolabeled antibody construct minimizes alpha particle emissions from the radionuclide and its alpha-particle emitting decay intermediates to non-targeted cells.
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