COMPOUNDS AND LIBRARIES OF PYRIDINES, PYRAZINES, IMIDAZO1,2-APYRAZINES AND 1H-IMIDAZO4,5-BPYRAZIN-2-ONES AND FIRST AND SECOND MEDICAL USES THEREOF

摘要

The present invention relates to pyridine,pyrazine,imidoz[1,2a]pyrazine and 1H-imidoz[4,5-b]pyrazin-2-one compounds capable of binding to the active site of protein kinase enzymes. The invention further relates to libraries of these compounds and a family of libraries of these compounds for use in screening programmes against protein kinases as well as the individual compounds for use in hit to lead and lead optimisation projects, and similar stages in the drug discovery process. The invention also provides methods for making compounds and libraries, thereof.