NASAL FORMULATIONS INCLUDING A TOPICAL DECONGESTANT AND A TOPICAL CORTICOSTEROID AND THEIR USE IN TREATMENT OF OBSTRUCTIVE SLEEP APNEA

摘要

A pharmaceutical formulation is provided for nasal drug administration of a topically administrable decongestant, a topically administrable corticosteroid and a pharmaceutically acceptable carrier, and may optionally include further carriers, therapeutic extenders, and the like. Such formulations may also optionally further include a therapeutically active member selected from the group consisting of a topical antibiotic, a topical antihistamine (preferably a non-sedating antihistamine), a leukotriene D4 antagonist, a 5-lipoxygenase inhibitor, and a FLAP antagonist, or a pharmaceutically acceptable salt thereof. In addition, methods for using the formulation to treat decongestant/corticosteroids-responsive conditions, diseases or disorders such as chronic obstructive nasal congestion and/or obstructive sleep apnea conditions, are provided, as are drugs delivery devices and dosage forms for housing and/or dispensing the formulations.