USE OF AN ORGAN-SPECIFIC SELF-PATHOGEN FOR TREATMENT OF A NON-AUTOIMMUNE DISEASE OF SAID ORGAN

摘要

An agent selected from: (a) a pathogenic self-antigen associated with a T-cell-mediated specificautoimmune disease of an organ; (b) a peptide which sequence is comprised within the sequenceof (a); (c) a peptide obtained by modification of (b), by replacement of one or more amino acidresidues by different amino acid residues, said modified peptide still being capable of recognizingthe T-cell receptor recognized by the parent peptide but with less affinity; (d) a nucleotide sequenceencoding (a), (b), or (c) ; and (e) T cells activated by a pathogenic self-antigen of (a), a peptide of (b), or a modified peptide of (c), can be used for treatment of a non- autoimmunedisease, disorder or injury in said organ. For example, uveitogenic antigens or peptides thereof canbe used for treatment of a non-autoimmune disease, disorder or injury in the eye.