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MOLECULES THAT SELECTIVELY HOME TO VASCULATURE OF PRE-MALIGNANT DYSPLASTIC LESIONS OR MALIGNANCIES
MOLECULES THAT SELECTIVELY HOME TO VASCULATURE OF PRE-MALIGNANT DYSPLASTIC LESIONS OR MALIGNANCIES
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机译:选择性地滋生恶性肿瘤前恶性病变或恶性肿瘤的分子
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摘要
The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences.
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机译:本发明提供了一种缀合物,其包含与归巢肽或拟肽连接的治疗部分,所述归巢肽或拟肽选择性地归巢于恶性前发育不良的皮肤的脉管系统,并且包括氨基酸序列SRPRR(SEQ ID NO:1)或保守变体或拟肽其。本发明进一步提供了包含与归巢肽或拟肽连接的治疗部分的缀合物,所述归巢肽或拟肽选择性地归巢于恶性皮肤的脉管系统,并且包括氨基酸序列CGKRK(SEQ ID NO:6)或氨基酸序列CDTRL(SEQ ID NO:6)。 NO:7),或这些序列之一的保守变体或拟肽。
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