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Azole derivatives and their use as superoxide radical inhibitors

机译:唑衍生物及其作为超氧化物自由基抑制剂的用途

摘要

A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), CHEM Äwherein R1 represents a phenyl group which may have 1-3 lower alkoxy groups as substituent(s) on the phenyl ring, a phenyl group having a lower alkylenedioxy group, or the like; R2 represents a hydrogen atom, a phenyl group, a halogen atom, a lower alkoxycarbonyl group, a lower alkyl group, an amino-lower alkyl group which may have a lower alkyl group as a substituent, a dihydrocarbostyril group, or the like; R3 represents a group of the formula, CHEM (R4B represents a hydroxyl group, a carboxy group, a lower alkenyl group or a lower alkyl group. m represents 0, 1 or 2); X represents a sulfur atom : Ü or a salt thereof.
机译:含有通式(1)表示的唑衍生物作为有效成分的超氧化物自由基抑制剂,其中R 1表示可以具有1-3个低级烷氧基作为取代基的苯基。苯环,具有低级亚烷基二氧基的苯基等。 R 2表示氢原子,苯基,卤素原子,低级烷氧羰基,低级烷基,可以具有低级烷基作为取代基的氨基-低级烷基,二烃基丁二唑基或喜欢; R 3表示式的基团,(R 4B表示羟基,羧基,低级烯基或低级烷基,m表示0、1或2)。 X代表硫原子:Ü或其盐。

著录项

  • 公开/公告号EP1130017B1

    专利类型

  • 公开/公告日2005-06-15

    原文格式PDF

  • 申请/专利权人 OTSUKA PHARMACEUTICAL CO. LTD.;

    申请/专利号EP20010112988

  • 申请日1991-11-29

  • 分类号C07D277/24;C07D277/30;C07D277/22;C07D277/56;C07D277/68;C07D263/32;C07D417/04;C07D417/14;C07D413/04;C07D513/04;C07F9/6539;C07H15/26;A61K31/42;A61K31/425;A61K31/70;A61K31/66;A61P9/10;

  • 国家 EP

  • 入库时间 2022-08-21 22:10:18

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