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Process for the preparation of (schiff bases of)alpha-alkyl-alpha-amino acid amides
Process for the preparation of (schiff bases of)alpha-alkyl-alpha-amino acid amides
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机译:制备α-烷基-α-氨基酸酰胺的(席夫碱)的方法
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摘要
Process for the preparation of a Schiff base of an α-alkyl-α-amino acid amide and an aldehyde, wherein the corresponding α-aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good contact. The Schiff base obtained may be further hydrolysed to form the α-alkyl-α-amino acid amide and the aldehyde.;Preferably a substituted or unsubstituted benzaldehyde is used as the aldehyde. The reaction is preferably carried out in a practically homogeneously mixed phase obtained by using a solvent, for example methanol or ethanol. Preferably NaOH or KOH is used as the base.
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